What is a POSLUMA PET Scan?

A POSLUMA PET scan is an advanced imaging test designed to detect and monitor prostate cancer. It uses a radiotracer called POSLUMA® (flotufolastat F 18), which specifically targets prostate-specific membrane antigen (PSMA). PSMA is a protein found in high amounts on prostate cancer cells, making this scan highly effective for precise detection.

Why is a POSLUMA PET Scan Important?

• Identify cancer spread: Locates metastases in bones, lymph nodes, or other tissues.
• Detect cancer recurrence: Especially in patients with rising PSA levels after initial treatment.
• Guide treatment decisions: Helps determine the best approach, whether surgery, radiation, or systemic therapies.
• Avoid unnecessary procedures: Provides accurate imaging to prevent ineffective treatments.

POSLUMA PET scans are more sensitive and specific than traditional imaging like bone scans, standard CT, or MRI.

How Does a POSLUMA PET Scan Work?

The radiotracer POSLUMA binds to PSMA-expressing cells in the body. Once injected, the tracer emits small amounts of radiation that the PET scanner detects. This creates a clear, detailed image of where cancer may be present.

What Happens During a POSLUMA PET Scan?

1. Preparation: Avoid eating or drinking (other than water) for at least 4–6 hours before the scan. Inform your healthcare provider about any medications or conditions.
2. Tracer Injection: A small amount of POSLUMA is injected into your bloodstream. You’ll wait about 60 minutes for the tracer to circulate and bind to PSMA proteins.
3. The Scan: You’ll lie on a motorized table that moves through the PET scanner. The scan is painless and takes about 20–30 minutes.
4. After the Scan: You can resume normal activities right away. Drink plenty of fluids to help flush the tracer from your system.

What Are the Benefits of POSLUMA PET Scans?

• High Sensitivity: Detects even small amounts of cancer.
• Early Detection: Identifies cancer recurrence or spread sooner than traditional methods.
• Improved Planning: Helps doctors develop targeted treatment strategies.
• Safe and Non-invasive: Minimal side effects and no need for surgery.

Are There Any Risks?

POSLUMA PET scans are safe, but there are minor risks, such as:

• Radiation exposure: Very low and within diagnostic safety limits.
• Allergic reactions: Rare but possible. Let your doctor know if you’ve had issues with similar tracers.

Who Should Consider a POSLUMA PET Scan?

• Patients with suspected metastatic prostate cancer.
• Individuals with rising PSA levels after prostate cancer treatment.
• Those who need precise imaging for treatment planning.

FAQs About POSLUMA PET Scans

How does POSLUMA compare to other PSMA PET scans?

POSLUMA is highly effective, offering similar or superior accuracy compared to other PSMA-targeted PET scans.

How long does the entire process take?

From check-in to completion, the process usually takes about 2–3 hours, including waiting for the tracer to circulate.

Is the scan covered by insurance?

Most insurance plans cover POSLUMA PET scans, especially for prostate cancer staging or recurrence. Confirm with your provider.

Are there alternatives to POSLUMA PET?

Other PSMA PET scans (e.g., Pylarify) are available. Your doctor will recommend the best option based on your needs.

Talk to Your Doctor

If you’ve been diagnosed with prostate cancer or suspect its recurrence, a POSLUMA PET scan could provide the critical information needed to guide your care. Discuss with your healthcare provider if this cutting-edge imaging test is right for you.